Cardiac electrophysiology : from cell to bedside / [edited by] Douglas P. Zipes, Jose Jalife.

Includes bibliographical references and index.

Part I. Structural and Molecular Bases of Ion Channel Function: Voltage-Gated Sodium Channels and Electrical Excitablility of the Heart -- Calcium Channels in the Heart -- Voltage-Regulated Potassium Channels -- Structural and Molecular Bases of Inward Rectifier Potassium Channel Function -- Mammalian Calcium Pumps in Health and Disease -- Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function -- Structural and Molecular Bases of Mitochondrial Ion Channel Function -- Molecular Organization, Gating, and Function of Gap Junction Channels -- Part II. Biophysics of Cardiac Ion Channel Function: Biophysics of Normal and Abnormal Cardiac Sodium Channel Function -- Regulation of Cardiac Calcium Channels -- KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease -- Structural Determinants and Biophysical Properties of hERG Channel Gating -- Molecular Regulation of Cardiac Inward Rectifier Potassium Channels by Pharmacologic Agents -- Cardiac Stretch-Activated Channels and Mechano-Electric Coupling -- Biophysical Properties of Gap Junctions -- Excitation-Contraction Coupling -- Part III. Intermolecular Interactions and Cardiomyocyte Electrical Function: Ion Channel Trafficking in the Heart -- Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5 -- Calmodulin and CaMKII as Ca2+ Switches for Cardiac Ion Channels -- Macromolecular Complexes and Cardiac Potassium Channels -- Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias -- The Intercalated Disc: A Molecular Network that Integrates Electrical Coupling, Intercellular Adhesion, and Cell Excitability -- Scaffolding Proteins and Ion Channel Diseases -- Epigenetics in Cardiac Rhythm Diseases --.

Part IV. Cell Biology of Cardiac Impulse Initiation and Propagation: Cardiac Impulse is Initiated by a Coupled System of Membrane Ion Channels and Ca2+ Cycling Proteins -- Biological Pacing -- Intercellular Communication and Impulse Propagation -- Mechanisms of Atrioventricular Nodal Excitability and Propagation -- Cell Biology of the Specialized Cardiac Conduction System -- Cardiac Fibroblasts and Arrhythmogenesis -- Part V. Models of Cardiac Excitation: Ionic Mechanisms of Atrial Action Potentials -- Models of the Ventricular Action Potential in Health and Disease -- Calcium Signaling in Cardiomyocyte Models with Realistic Geometries -- Theory of Rotors and Arrhythmias -- Supraventricular Arrhythmias in a Realistic 3D Model of the Human Atria -- Cardiac Electromechanical Models -- Part VI. Neural Control of Cardiac Electrical Activity: Cav1.2 and -Adrenergic Regulation of Cardiac Function -- Cholinergic and Constitutive Regulation of Atrial Potassium Channel -- Pulmonary Vein Ganglia and the Neural Regulation of the Heart Rate -- Neural Activity and Atrial Tachyarrhythmias -- Sympathetic Innervation, Denervation, and Cardiac Arrhythmias -- Part VII. Arrhythmia Mechanisms: Dominant Frequency and the Mechanisms of Initiation and Maintenance of Atrial Fibrillation -- Rotors in Human Atrial Fibrillation -- Atrial Ischemia and Fibrillation -- The Molecular Pathophysiology of Atrial Fibrillation -- Myofibroblasts, Cytokines and Persistent Atrial Fibrillation -- Role of the Autonomic Nervous System in Atrial Fibrillation -- Mechanisms of Ventricular Tachycardia and Fibrillation --.

Part VIII. Molecular Genetics and Pharmacogenomics: Genetics of Atrial Fibrillation -- Mechanisms in Heritable Sodium Channel Diseases -- Inheritable Potassium Channel Disease -- Genetics and Cellular Mechanisms of the J Wave Syndromes -- Inheritable Phenotypes Associated with Altered Intracellular Calcium Regulation -- Part IX. Pharmacologic, Genetic and Cell Therapy of Ion Channel Dysfunction: Pharmacologic Bases of Antiarrhythmic Therapy -- Pharmacogenomics of Cardiac Arrhythmias -- Optogenetic Control of Heart Muscle -- Cell Therapy and Regenerative Electrophysiology -- Part X. Diagnostic Evaluation: Assessment of the Patient with a Cardiac Arrhythmia -- Differential Diagnosis of Narrow and Wide Complex Tachycardias -- Mapping and Imaging -- CT and MR Imaging for Electrophysiology -- Intracardiac Echocardiography for Electrophysiology -- Exercise-Induced Arrhythmias -- Cardiac Monitoring: Short and Long-Term Recording -- Electrocardiographic Imaging in Patients with Acute Coronary Syndrome -- Head-up Tilt Table Testing -- Autonomic Testing and Cardiac Risk -- Monophasic Action Potential Recording -- T-Wave Alternans -- Noninvasive Electrocardiographic Imaging of Human Ventricular Arrhythmias and Electrophysiological Substrate -- Genetic Testing --.

Part XI. Supraventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management: Sinus Node Abnormalities -- Atrial Tachycardia -- Typical and Atypical Atrial Flutter: Mapping and Ablation -- Atrial Fibrillation: Paroxysmal, Persistent, and Permanent -- Preexcitation, Atrioventricular Reentry, and Variants -- Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Reentrant Circuits -- Atrial Tachyarrhythmias in Adults With Congenital Heart Disease -- Junctional Tachycardia -- Part XII. Ventricular Tacharrhythmias: Mechanisms, Clinical Features, and Management: Premature Ventricular Complexes -- Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management -- Fascicular Ventricular Arrhythmias -- Bundle Branch Reentry Tachycardia -- Ischemic Heart Disease -- Ventricular Tachycardia in Patients with Dilated Cardiomyopathy -- Ventricular Arrhythmias in Hypertrophic Cardiomyopathy -- Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy --.

VTs in Catecholaminergic Cardiomyopathy (Catecholaminergic Polymorphic Ventricular Tachycardia) -- Ventricular Arrhythmias in Heart Failure -- Ventricular Tachycardia in Noncompaction Cardiomyopathy -- Ventricular Arrhythmias in Takatsubo Cardiomyopathy -- Brugada Syndrome 1992-2012: Twenty Years of Scientific Progress -- Long and Short QT Syndromes -- Andersen-Tawil Syndrome -- Timothy Syndrome -- J Wave Syndromes -- Idiopathic Ventricular Fibrillation -- Sudden Infant Death Syndrome -- Sudden Cardiac Death in Adults -- Arrhythmias in Patients with Neurologic Disorders -- Drug-Induced Ventricular Tachycardia -- Ventricular Arrhythmias in Congenital Heart Disease -- Part XIII. Syncope and AV Block: Syncope -- Postural Orthostatic Tachycardia Syndrome -- Progressive Conduction System Disease -- Atrioventricular Block -- Part XIV. Arrhythmias in Special Populations: Sex Differences in Arrhythmias -- Sudden Cardiac Deaths in Athletes, Including Commotio Cordis -- Arrhythmias in Pediatric Population -- Sleep-Disordered Breathing and Arrhythmias --.

Part XV. Pharmocologic Therapy: Standard Antiarrhythmic Drugs -- New Antiarrhythmic Drugs and New Concepts for Old Drugs -- Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death -- Prevention of Stroke with Atrial Fibrillation -- Part XVI. Electrical Therapy: Implantable Cardioverter Defibrillators: Technical Aspects -- Implantable Cardioverter Defibrillator: Clinical Aspects -- Implantable Pacemakers -- Cardiac Resynchronization Therapy -- Newer Applications of Pacemakers -- Catheter Ablation: Technical Aspects -- Catheter Ablation: Clinical Aspects -- Ablation for Atrial Fibrillation -- Ablation of Supraventricular Tachyarrhythmias -- Catheter Ablation for Ventricular Tachycardia in Patients with Structural Heart Disease -- Special Ablation Approaches: Epicardial, Other -- Ablation in Pediatrics -- Catheter Ablation in Congenital Heart Disease -- Part XVII. Surgery for Arrhythmias: Atrial Fibrillation and Other SVTs -- Surgery for Ventricular Arrhythmias -- Part XVIII. New Approaches: Vagal Stimulation for Heart Failure -- Spinal Cord Stimulation for Heart Failure and Arrhythmias -- Left Atrial Occluders/Isolation.