The design of animal experiments : reducing the use of animals in research through better experimental design / Michael F.W. Festing, Philip Overend, Mario Cortina Borja, Manuel Berdoy.

"Laboratory Animals Limited"--Cover.

Includes bibliographical references and index.

Introduction and basic principles -- Choice of animals and their husbandry -- Understanding and controlling variation -- The analysis of variance -- The completely randomised single factor design -- Factorial experiments -- Randomised block design -- Split plots, Latin squares, covariance and other techniques -- Counts and proportions -- Regression and correlation -- The determination of sample size -- Seventeen steps in designing a randomised controlled animal experiment -- Reporting the results -- Appendix 1: R-Commander : a free menu-driven statistical software package -- Appendix 2: Further reading.